Development of a Novel 1,25(0H),-Vitamin D, Analog With Potent Ability to Induce HL-60 Cell Differentiation Without Modulating Calcium Metabolism
نویسندگان
چکیده
We describe several novel analogs of the seco-steroid 1,25(0H),-vitamin D,[1.25(OH),D3] and their effects on differentiation and proliferation of HL-60 human myeloid leukemic cells in vitro as well as their effects on calcium metabolism in vivo. The la-25(OH),-16ene-23yne-26,27Fo-vitamin D, is the most potent analog reported to date, having about 80-fold more activity than the reference 1,25(OH),D3 for inhibition of proliferation and induction of differentiation of HL-60 cells. Also, this analog decreased RNA expression of MYC oncogene in HL-60 by 90% at 5 x IO-'' mol/L. Intriguingly, intestinal calcium absorption and bone calcium mobilization
منابع مشابه
Development of a novel 1,25(OH)2-vitamin D3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism.
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